赵丽娇 教授，博士生导师
联系电话：13910167017
E-mail：zhaolijiao@bjut.edu.cn
通讯地址：北京市朝阳区平乐园100号北京工业大学理科楼B213室
教育背景
2006年毕业于北京工业大学生命科学与生物工程学院，获生物医学工程专业博士学位
工作经历
2006.07至2008.11 北京工业大学生命科学与生物工程学院，讲师
2008.04至2008.10 美国麻省理工学院，访问学者
2008.12至2014.06 北京工业大学生命科学与生物工程学院，副教授
2012.06至2013.06 美国明尼苏达大学，访问学者
2014.07至2020.04北京工业大学生命科学与生物工程学院，教授
2020.04至今北京工业大学化学与生命科学学院，教授
研究方向
1. 肿瘤靶向性多功能纳米载体
2. 新型靶向性抗肿瘤药物的设计、合成及活性研究
3. 环境致癌物对生物大分子的损伤作用及癌症生物标志物
4. 致癌物的代谢和致癌作用机理及其分子结构与致癌活性关系
5. 烷化剂类抗肿瘤药物的耐药机制
课程教学
1. 本科生课程：仪器分析（双语）
2. 本科生课程：化学生物学
3. 研究生课程：现代仪器分析实验
4. 研究生课程：环境与病毒肿瘤学
5. 研究生课程：现代化学进展
奖项荣誉
1. 2020年入选北京市“百千万”人才工程
2. 2018年入选北京市“长城学者”计划
3. 2009年入选北京市留学人员科技活动择优资助计划
4. 2009年入选北京市“科技新星”计划
5. 2008年入选北京市委组织部“优秀人才”计划
6. 2015年入选北京工业大学“京华人才”计划
主要科研项目
1. 国家自然科学基金面上项目（2018.01-2021.12，项目负责人）：低氧激活联合亚硝基脲的作用机理及抗癌活性研究
2. 国家自然科学基金面上项目（2013.01-2016.12，项目负责人）：环境中N-亚硝基化合物分子结构与致癌活性关系及其生物标志物研究
3. 国家自然科学基金青年基金项目（2010.01-2012.12，项目负责人）：N-亚硝基化合物对DNA的损伤作用机制及相关构效关系
4. 北京市百千万人才支持计划（2020.01-2021.12，项目负责人）：肿瘤低氧靶向性亚硝基脲纳米递送载体的构建及其活性评价
5. 北京市长城学者支持计划（2018.01-2021.04，项目负责人）：低氧靶向性抗癌烷化剂的开发
6. 北京市自然科学基金面上项目（2016.01-2018.12，项目负责人）：新型靶向性抗耐药亚硝基脲类烷化剂的设计、合成及抗肿瘤活性研究
7. 北京工业大学“京华人才”支持计划（2015.01-2017.12，项目负责人）：新型靶向性亚硝基脲类抗癌药物的研究
8. 北京市留学人员科技活动择优资助项目（2015.01-2015.12，项目负责人）：烟草特异亚硝胺导致肺癌的生物标志物研究
9. 北京市科技新星计划B类（2010.01-2012.12，项目负责人）：N-亚硝基化合物对DNA的损伤作用及致癌机理研究
10. 北京市委组织部优秀人才资助项目（2008.01-2009.12，项目负责人）：癌症相关标志物及应用研究
主要论文论著及专利
[1] Jiaojiao Wang; Ting Ren; Guohui Sun; Na Zhang; Lijiao Zhao*; Rugang Zhong. Mechanism of AGT-mediated repair of dG-dC cross-links in the drug resistance to chloroethylnitrosoureas: molecular docking, MD simulation, and ONIOM (QM/MM) investigation. Journal of Chemical Information and Modeling, 2024, 64(8): 3411-3429. (SCI检索，中科院2区TOP期刊)
[2] Xiaoyu Li; Ran Kong; Wenhao Hou; Junxia Cao; Li Zhang; Xiaohong Qian; Lijiao Zhao*; Wantao Ying*. Integrative proteomics and N-glycoproteomics reveal the synergistic anti-tumor effects of aspirin- and gemcitabine-based chemotherapy on pancreatic cancer cells. Cellular Oncology, 2024, 47(1): 141-156. (SCI检索)
[3] Duo Li; Ting Ren; Yunxuan Ge; Xiaoli Wang; Guohui Sun; Na Zhang; Lijiao Zhao*; Rugang Zhong. A multi-functional hypoxia/esterase dual stimulus responsive and hyaluronic acid-based nanomicelle for targeting delivery of chloroethylnitrosouea. Journal of Nanobiotechnology, 2023, 21(1): 291. (SCI检索，中科院1区TOP期刊)
[4] Duo Li; Xiaoli Wang; Kaishuo Han; Yaqian Sun; Ting Ren; Guohui Sun; Na Zhang; Lijiao Zhao*; Rugang Zhong. Hypoxia and CD44 receptors dual-targeted nano-micelles with AGT-inhibitory activity for the targeting delivery of carmustine. International Journal of Biological Macromolecules, 2023, 246: 125657. (SCI检索，中科院1区TOP期刊)
[5] Duo Li; Ting Ren; Xiaoli Wang; Zhixuan Xiao; Guohui Sun; Na Zhang; Lijiao Zhao*; Rugang Zhong. Development and in vitro evaluation of carmustine delivery platform: A hypoxia-sensitive anti-drug resistant nanomicelle with BBB penetrating ability. Biomedicine & Pharmacotherapy, 2023, 167: 115631. (SCI检索，中科院1区TOP期刊)
[6] Qi Liu; Xiaoli Wang; Jun Li; Jiaojiao Wang; Guohui Sun; Na Zhang; Ting Ren; Lijiao Zhao*; Rugang Zhong. Development and biological evaluation of AzoBGNU: A novel hypoxia-activated DNA crosslinking prodrug with AGT-inhibitory activity. Biomedicine & Pharmacotherapy, 2021, 144: 112338. (SCI检索，中科院2区TOP期刊)
[7] Guohui Sun*; Yifan Zhang; Luyu Pei; Yuqing Lou; Yao Mu; Jiayi Yun; Feifan Li; Yachen Wang; Zhaoqi Hao; Sha Xi; Chen Li; Chuhan Chen; Lijiao Zhao*; Na Zhang; Rugang Zhong; Yongzhen Peng. Chemometric QSAR modeling of acute oral toxicity of polycyclic aromatic hydrocarbons (PAHs) to rat using simple 2D descriptors and interspecies toxicity modeling with mouse. Ecotoxicology and Environmental Safety, 2021, 222: 112525. (SCI检索，中科院2区TOP期刊)
[8] Chang Liu; Xiaoxia Si; Shumei Yan; Xinyuan Zhao; Xiaohong Qian; Wantao Ying*; Lijiao Zhao*. Development of the C12Im-Cl-assisted method for rapid sample preparation in proteomic application. Analytical Methods, 2021, 13(6): 776-781. (SCI检索)
[9] Fangzheng Yin; Lijiao Zhao*; Lili Zhang; Yuhe Chen; Guohui Sun; Jintao Li; Na Zhang; Yuancong Xu; Paul Kay-Sheung Chan; Rugang Zhong. Chemopreventive role of apigenin against the synergistic carcinogenesis of human papillomavirus and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biomedicines, 2020, 8: 472. (SCI检索)
[10] Zhuochen Zhuang; Jintao Li; Guohui Sun; Xin Cui; Na Zhang; Lijiao Zhao*; Paul Kay-Sheung Chan; Rugang Zhong. Synergistic effect between human papillomavirus 18 and 4-(methyl- nitrosamino)-1-(3-pyridyI)-1-butanone on malignant transformation of immortalized SHEE cells. Chemical Research in Toxicology, 2020, 33(234): 470-481. (SCI检索)
[11] Yao Ge; Xinxin Lai; Jintao Li; Ran Yu; Zhuochen Zhuang; Guohui Sun; Xin Cui; Na Zhang; Lijiao Zhao*; Pramod Upadhyaya; Rugang Zhong. NBGNU: a hypoxia-activated tripartite combi-nitrosourea prodrug overcoming AGT-mediated chemoresistance. Future Medicinal Chemistry, 2019, 11(4): 269-284. (SCI检索)
[12] Weinan Xiao; Guohui Sun; Tengjiao Fan; Junjun Liu; Na Zhang; Lijiao Zhao*; Rugang Zhong. Reductive activity and mechanism of hypoxia targeted AGT inhibitors: An experimental and theoretical investigation. International Journal of Molecular Sciences, 2019, 20: 6308. (SCI检索)
[13] Guohui Sun; Lijiao Zhao*; Rugang Zhong; Yongzhen Peng. The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy. Future Medicinal Chemistry, 2018, 10(16): 1971-1996. (SCI检索)
[14] Tengjiao Fan; Guohui Sun; Lijiao Zhao*; Xin Cui; Rugang Zhong. QSAR and classification study on prediction of cute oral toxicity of N-nitroso compounds. International Journal of Molecular Sciences, 2018, 19: 3015. (SCI检索)
[15] Guohui Sun; Tengjiao Fan; Xiaodong Sun; Yuxing Hao; Xin Cui; Lijiao Zhao*; Ting Ren; Yue Zhou; Rugang Zhong; Yongzhen Peng. In silico prediction of O6-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods. Molecules, 2018, 23: 2892. (SCI检索)
[16] Guohui Sun; Tengjiao Fan; Lijiao Zhao*; Yue Zhou; Rugang Zhong. The potential of combi-molecules with DNA-damaging function as anticancer agents. Future Medicinal Chemistry, 2017, 9(4): 403-435. (SCI检索)
[17] Yameng Wang; Ting Ren; Xinxin Lai; Guohui Sun; Lijiao Zhao*; Na Zhang; Rugang Zhong. Synthesis and antitumor activity evaluation of a novel combinitrosourea prodrug: BGCNU. ACS Medicinal Chemistry Letters, 2017, 8: 174-178. (SCI检索)
[18] Ting Ren; Xi Chen; Yao Ge; Lijiao Zhao*; Rugang Zhong. Determination of heavy metals in cigarettes using high-resolution continuum source graphite furnace atomic absorption spectrometry. Analytical Methods, 2017, 9(27): 4033-4043. (SCI检索)
[19] Guohui Sun; Lijiao Zhao*; Tengjiao Fan; Ting Ren; Rugang Zhong. Measurement of O-6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS. Journal of Chromatography B, 2016, 1033: 138-146. (SCI检索)
[20] Guohui Sun; Tengjiao Fan; Na Zhang; Ting Ren; Lijiao Zhao*; Rugang Zhong. Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking. Molecules, 2016, 21(7): 823-843. (SCI检索)
[21] Guohui Sun; Na Zhang; Lijiao Zhao*; Tengjiao Fan; Shufen Zhang; Rugang Zhong. Synthesis and antitumor activity evaluation of a novel combi- nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O-6-alkylguanine-DNA alkyltransferase. Bioorganic & Medicinal Chemistry, 2016, 24(9): 2097-2107. (SCI检索)
[22] Guohui Sun; Lijiao Zhao*; Rugang Zhong. The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 2016, 16(2): 221-246. (SCI检索)
[23] Wensi Zhong; Ting Ren; Lijiao Zhao*. Determination of Pb (Lead), Cd (Cadmium), Cr (Chromium), Cu (Copper), and Ni (Nickel) in Chinese tea with high-resolution continuum source graphite furnace atomic absorption spectrometry. Journal of Food and Drug Analysis, 2016, 24 (1): 46-55. (SCI检索)
[24] Guohui Sun; Lijiao Zhao*; Tengjiao Fan; Sisi Li; Rugang Zhong. Investigations on the effect of O6-benzylguanine on the formation of dG-dC interstrand crosslinks induced by chloroethylnitrosoureas in human glioma cells using a stable isotope dilution high- performance liquid chromatography- electrospray ionization tandem mass spectrometry. Chemical Research in Toxicology, 2014, 27(7): 1253-1262. (SCI检索)
[25] Lili Li; Lijiao Zhao*; Rugang Zhong. Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high- performance liquid chromatography/ electrospray ionization tandemmass spectrometry. Rapid Communications in Mass Spectrometry, 2014, 28(5): 439-447. (SCI检索)
[26] Lijiao Zhao*; Lili Li; Jie Xu; Rugang Zhong. Comparative investigation of the DNA inter-strand crosslinks induced by ACNU, BCNU, CCNU and FTMS using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. International Journal of Mass Spectrometry, 2014, 368(7): 30-36. (SCI检索)
[27] Lijiao Zhao; Silvia Balbo; Mingyao Wang; Pramod Upadhyaya; Samir S. Khariwala; Peter W. Villalta; Stephen S. Hecht*. Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N′- nitrosonornicotine (NNN) in a carcinogenicity study. Chemical Research in Toxicology, 2013, 26(10): 1526-1535. (SCI检索)
[28] Tingting Liu; Lijiao Zhao*; Rugang Zhong. DFT investigations of phosphotriesters hydrolysis in aqueous solution: a model for DNA single strand scission induced by N-nitrosoureas. Journal of Molecular Modeling, 2013, 19(2): 647-659. (SCI检索)
[29] Lijiao Zhao*; Xinyan Ma; Rugang Zhong. A DFT investigation on the formation mechanisms of DNA interstrand crosslinks induced by chloroethyl- nitrosoureas. International Journal of Quantum Chemistry, 2013, 113(9): 1299-1306. (SCI检索)
[30] Ting Ren; Lijiao Zhao*; Bosi Sun; Rugang Zhong. Determination of lead, cadmium, copper, and nickel in the tonghui river of Beijing, China, by cloud point extraction-high resolution continuum source graphite furnace atomic absorption spectrometry. Journal of Environmental Quality, 2013, 42(6): 1752-1762. (SCI检索)
[31] Lijiao Zhao*; Ting Ren; Rugang Zhong. Determination of lead in human hair by high resolution continuum source graphite furnace atomic absorption spectrometry with microwave digestion and solid sampling. Analytical Letters, 2012, 45(16): 2467-2481. (SCI检索)
[32] Jun Cao; Lijiao Zhao*; Shubin Jin; Rugang Zhong. Relationship between the molecular structure and the anticancer activity of N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosoureas: A theoretical investigation. International Journal of Quantum Chemistry, 2012, 112(3): 747-758. (SCI检索)
[33] Baoqing Bai; Lijiao Zhao*; Rugang Zhong. Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2011, 25(14): 2027-2034. (SCI检索)
发明专利授权：
[1] 赵丽娇; 王娇娇; 李多; 孙国辉; 张娜; 钟儒刚. 一种兼有抗耐药性和低氧/谷胱甘肽双重响应的多功能纳米载体及其制备方法和应用, 2024-04-04, 中国, 授权专利号ZL202110991432.3
[2] 赵丽娇; 李多; 韩凯硕; 孙国辉; 张娜; 钟儒刚. 一种兼有抗耐药性和低氧/酯酶双重响应的多功能纳米载体的制备方法和应用, 2023-05-12, 中国, 授权专利号ZL202110950336.4
[3] 赵丽娇; 王娇娇; 李多; 孙国辉; 张娜; 钟儒刚. 肿瘤靶向性抗耐药O6-噻吩甲基鸟嘌呤-吲哚醌-氯乙基亚硝基脲联合分子及其制备方法, 2022-07-12, 中国, 授权专利号ZL2021109511854
[4] 赵丽娇; 刘琪; 李多; 孙国辉; 张娜; 钟儒刚. 一种低氧双靶向性AGT抑制剂偶联物及其制备方法与应用, 2022-08-09, 中国, 授权专利号ZL202010209706.4
[5] 赵丽娇; 张黎黎; 孙国辉; 张娜; 钟儒刚. 一种低氧靶向性AGT抑制剂偶联物及其制备方法和应用,2021-11-12, 中国, 授权专利号ZL201910743520.4
[6] 赵丽娇; 余然; 张黎黎; 宋秀庆; 钟儒刚. 靶向肿瘤低氧的偶氮芳香氮氧化物-氯乙基亚硝基脲偶联分子及其制备方法和应用, 2020-1-17, 中国, 授权专利号ZL201810200016.5
[7] 赵丽娇; 余然; 葛瑶; 任婷; 宋秀庆; 钟儒刚. 一种偶氮芳香氮芥氯乙基亚硝基脲偶联的化合物及制备方法和应用, 2019-12-25, 中国, 授权专利号ZL201711049998.4
[8] 赵丽娇; 刘俊俊; 赖新鑫; 宋秀庆; 任婷; 钟儒刚. 低氧激活O6-苄基-2-硝基嘌呤衍生物及制法和应用, 2019-10-25, 中国, 授权专利号ZL201710377712.9
[9] 赵丽娇; 赖新鑫; 孙国辉; 任婷; 宋秀庆; 钟儒刚. 一种低氧激活AGT蛋白抑制剂及其制备方法与应用, 2017-9-12, 中国, 授权专利号ZL201610448022.3
[10] 赵丽娇; 彭瑞增; 任婷; 张淑芬; 钟儒刚. 低氧激活联合氯乙基亚硝基脲类化合物及制备方法和应用, 2017-9-5, 中国, 授权专利号ZL201511017787.3
[11] 赵丽娇; 孙国辉; 钟儒刚. 一种新型的β-氯乙基亚硝基脲类化合物及其合成方法和用途, 2015-12-04, 中国, 授权专利号ZL201410231997.1
[12] 赵丽娇; 李莉莉; 王雅朦; 钟儒刚. 一种具有抗癌活性的氯乙基亚硝基脲及其合成方法, 2016-3-9, 中国, 授权专利号ZL201410231185.7
