袁卿  硕士生导师、来华留学生博士生导师

        E-mail：yuanqing@bjut.edu.cn

       联系方式：15001009720

       通讯地址：北京市朝阳区平乐园100号，环能楼C703

教育背景

2004年9月-2008年6月 兰州大学 生物学国家基地班 学士

2008年9月-2011年6月 兰州大学 生物物理学 硕士

2015年9月-2018年6月 中国科学院大学 生物无机化学 博士

工作经历

2011年7月-2013年9月，中国科学院高能物理研究所，纳米生物效应与安全性重点实验室，助理工程师

2013年10月-2018年7月，中国科学院高能物理研究所，纳米生物效应与安全性重点实验室，工程师

2018年8月-2021年6月，北京工业大学，环境与生命学部，助理研究员

2021年7月-至今，北京工业大学，环境与生命学部，副研究员

研究方向

1. 生物医药活性金属纳米药物开发与靶向递送；

2. 贵金属纳米团簇在恶性肿瘤和免疫疾病诊疗中的应用与优化设计；

3. 金属纳米材料免疫调控机制解析与功能化。

课程教学

本科生课程：生物化学实验

硕士生课程：化学生物学 

奖项荣誉

北京工业大学优秀硕士论文指导教师

挑战杯全国大学生课外学术科技作品竞赛一等奖指导教师

全国大学生生命科学竞赛（科学探究类）三等奖指导教师

主要科研项目

1. 国家自然科学基金面上项目，多肽纳米金簇抑制肺部细胞因子风暴的生物效应研究，2022.01-2025.12，主持

2. 国家重点研发计划子课题，高分子纳米药物器官靶向适配规律及分子机制，2021.12-2026.11，项目骨干

3. 国家自然科学基金青年项目，多肽复合纳米金簇对慢性淋巴细胞白血病的生物活性研究及优化设计，2018.01-2020.12，主持

4. 北京市教育委员会科技计划一般项目，NF-kappa B拮抗肽组装纳米金簇用于弥漫大B细胞淋巴瘤多靶点协同治疗的基础研究，2021.01-2023.12，主持

主要论文论著、专利

1. Lu, Cao; Xue, Liyuan; Luo, Kaidi; Liu, Yu; Lai, Jing; Yao, Xiuxiu; Xue, Yiling; Huo, Wendi; Meng, Cong; Xia, Dongfang; Gao, Xueyun; Yuan, Qing^*; Cao, Kai^*, Colon-Accumulated Gold Nanoclusters Alleviate Intestinal Inflammation and Prevent Secondary Colorectal Carcinogenesis via Nrf2-Dependent Macrophage Reprogramming. ACS Nano, 2023, 17 (18), 18421-18432. (^*Corresponding author)

2. Meng, Cong; Liu, Yu; Ming, Yuping; Lu, Cao; Li, Yanggege; Zhang, Yulu; Su, Dongdong^*; Gao, Xueyun; Yuan, Qing^*, Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation. Pharmaceutics, 2024, 16 (1), 110.

3. Lai, Jing^#; Yao, Yawen^#; Zhang, Yulu; Liu, Yu; Lu, Cao; Meng, Cong; Xia, Dongfang; Li, Yanggege; Cao, Kai; Gao, Xueyun^*; Yuan, Qing^*; Cell-Penetrating Peptide Conjugated Au Nanoclusters Selectively Suppress Refractory Lymphoma Cells via Targeting Both Canonical and Noncanonical NF-κB Signaling Pathways. Bioconjugate chemistry, 2023, 34(1), 228–237.

4. Chen, Xueqian; Niu, Wenchao; Yuan, Qing^*; Zhang, Yong; Gao, Xueyun; Su, Dongdong^*; Mapping the endogenous Zn2+ in situ during zebrafish embryogenesis by a fluorogenic sensor. Sensors and Actuators B: Chemical, 2023, 376, 132937.

5. Yao, Yawen; Lu, Cao; Gao, Liang; Cao, Kai; Yuan, Hui; Zhang, Xiangchun; Gao, Xueyun^*; Yuan, Qing^*; Gold Cluster Capped with a BCL-2 Antagonistic Peptide Exerts Synergistic Antitumor Activity in Chronic Lymphocytic Leukemia Cells. ACS applied materials & interfaces, 2021, 13 (18), 21108-21118.

6. Zhang, Zhichao^#; Yao, Yawen^#; Yuan, Qing^*; Lu, Cao; Zhang, Xiangchun; Yuan, Jinling; Hou, Kaixiao; Zhang, Chunyu; Du, Zhongying; Gao, Xueyun^*; Chen, Xiongsheng^*; Gold clusters prevent breast cancer bone metastasis by suppressing tumor-induced osteoclastogenesis, Theranostics, 2020, 10(9): 4042-4055.

7. Yuan, Qing; Gao, Fuping; Yao, Yawen; Cai, Pengju; Zhang, Xiangchun; Yuan, Jinling; Hou, Kaixiao; Gao, Liang; Ren, Xiaojun; Gao, Xueyun*; Gold Clusters Prevent Inflammation-Induced Bone Erosion through Inhibiting the Activation of NF-kappa B Pathway, Theranostics, 2019, 9(7): 1825-1836.

8. Liu, Yu; Meng, Cong; Li, Yanggege; Xia, Dongfang; Lu, Cao; Lai, Jing; Zhang, Yulu; Cao, Kai; Gao, Xueyun^*; Yuan, Qing^*; Peptide-Protected Gold Nanoclusters Efficiently Ameliorate Acute Contact Dermatitis and Psoriasis via Repressing the TNF-α/NF-κB/IL-17A Axis in Keratinocytes. Nanomaterials, 2023, 13(4), 662.

9. Yuan, Jinling; Hou, Kaixiao; Yao Yawen; Du, Zhongying; Lu, Cao; Yuan, Qing^*; Gao, Xueyun^*; Gold Clusters Attenuate Inflammation in Rat Mesangial Cells via Inhibiting the Activation of NF-κB Pathway[J]. Nanomaterials, 2020, 10(4):712.

10. Yuan, Qing^#; Zhao, Yao^#; Cai, Pengju; He, Zhesheng; Gao, Fuping^*; Zhang, Jinsong; Gao, Xueyun^*; Dose-Dependent Efficacy of Gold Clusters on Rheumatoid Arthritis Therapy, ACS Omega, 2019, 4(9): 14092-14099. (^#Equal contribution)

11. Li, Qiong^#; Yuan, Qing^#; Zhao, Mohan; Yao, Yawen; Gao, Liang; Liu, Ru; Wang, Yaling; Gong, Yong; Gao, Fuping^*; Gao, Xueyun^*; Au nanoclusters suppress chronic lymphocytic leukaemia cells by inhibiting thioredoxin reductase 1 to induce intracellular oxidative stress and apoptosis, Science Bulletin, 2017, 62(8): 537-545. (^#Equal contribution)

12. Yuan, Qing; Wang, Yaling; Zhao, Lina; Liu, Ru; Gao, Fuping; Gao, Liang^*; Gao, Xueyun^*; Peptide protected gold clusters: chemical synthesis and biomedical applications, Nanoscale, 2016, 8(24): 12095-12104.

13. Yuan, Qing; Han, Jing; Cong, Wenshu; Ge, Ying; Ma, Dandan; Dai, Zhaoxia; Li, Yaping^*; Bi, Xiaolin^*; Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity, International Journal of Nanomedicine, 2014, 9: 4829-4846.

14. Gao, Fuping^#; Yuan, Qing^#; Gao, Liang; Cai, Pengju; Zhu, Huarui; Liu, Ru; Wang, Yaling; Wei, Yueteng; Huang, Guodong; Liang, Jian; Gao, Xueyun^*; Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles, Biomaterials, 2014, 35(31): 8854-8866. (^#Equal contribution)

15. Kong, Ling^#; Yuan, Qing^#; Zhu, Huarui; Li, Ying; Guo, Quanyi; Wang, Qin; Bi, Xiaolin^*; Gao, Xueyun^*, The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis, Biomaterials, 2011, 32(27), 6515-22. (^#Equal contribution)