胡利明 博士生导师

联系电话：

E-mail：huliming@bjut.edu.cn

通讯地址：北京市朝阳区平乐园100号

教育背景

1998-9 至 2001-07，武汉大学，有机化学，博士

1991-9 至 1994-7，华中师范大学，有机化学，硕士

1981-9至 1985-7，华中师范大学，化学，学士

工作经历

2002-7至2004-6，厦门大学博士后

研究方向

荧光探针、药物化学

课程教学

本科生课程：有机化学

本科生课程：化学生物学专业实验

研究生课程：物理有机化学

研究生课程：高等有机化学

主要科研项目

北京市面上基金、国家面上基金等

主要论文论著

1. Leifu Yang, Yaxin Li, Yunling Du, Yan Guo, Zhenke Guo, Baoxiu Liu, Jianglin Liu, Yanfei Liu, Hongdan Niu, Yueming Sun, Henglin Yan, Yajuan Yang, Shannan Yu, Yifan Zhang, Yuan Zhang, Kun Zheng, Nanqiao Zheng, Xiaoqing Zhang, Qiang Zhang, and Liming Hu*. Discovery of Novel 5,6-Dihydro-4H-pyrido[2,3,4-de]quinazoline Irreversible Inhibitors Targeting Both Wild-Type and A775_G776insYVMA Mutated HER2 Kinases. Journal of Medicinal Chemistry 2024, 67, 7: 5662-5682

2. Yaxin Li; Sisi Liu; Ximing Xu; Jiamin Xu; Leifu Yang; Liming Hu; Integrated molecularmodeling and dynamics approaches revealed the mechanism of selective inhibition of HDAC6/8, Journal of Biomolecular Structure and Dynamics, 2023, 41(18):1-14.

3. Haoru Fan; Dengshuai Wei; Kun Zheng; Xuemei Qin; Leifu Yang; Yajuan Yang; Ye Duan; Yinsheng Xu; Liming Hu ; Discovery of Dioxino[2,3-f]quinazoline derivative VEGFR-2 inhibitor sexerting significant antipro-liferative activity in HUVECs and mice, &European journal of medicinal chemistry,2019,175:349-356

4. Dengshuai Wei; Fan Haoru; Kun Zheng; Xuemei Qin; Leifu Yang; Yajuan Yang; Ye Duan; QiangZhang; Cheng-Chu Zeng; Liming Hu ; Synthesis and anti-tumor activity of [1,4]dioxino [2, 3-f] quinazoline derivatives as dual inhibitors of c-Met and VEGFR-2, Bioorganic Chemistry, 2019, 88: 102916-102916.

5. Li, Hongxia; Zhang, Meiying; Linghu, Engiang; Zhou, Fuyou; Herman, James G; Hu, Liming;Guo, Mingzhou ; Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellularcarcinoma,CLINICAL EPIGENETICS,2018,10:137-137.

6. Wu-Yi Xiao; Yi wang; Hong-Wei An; Dayong Hou; Muhetaerjiang Mamuti; Man-Di Wang; JieWang; Wanhai Xu; Liming Hu; Hao Wang ; Click Reaction-Assisted Peptide Immune Checkpoint Blockade for Solid Tumor Treatment, ACS Applied Materials & Interfaces, 2020, 12(36): 40042-40051.